In diabetic neuropathy, one in five partial foot amputations require reamputation.

Diabetic foot ulcer

This systematic review set out to establish the success rate of partial first ray (medial toe and metatarsal) amputation for patients with diabetic neuropathy and an infected, ulcerated foot. Clinical question: In people with diabetic peripheral neuropathy and infected, ulcerated foot, what is the outcome of partial first ray amputation? The evidence: The researchers found [read the full story…]

Valproate may be effective in treating pain from diabetic neuropathy

An elderly male patient with a nurse

Clinical question In diabetics with painful neuropathy, does valproic acid or sodium valproate reduce pain? Methods Systematic review of randomised trials.  Three trials were found, two of which examined diabetic neuropathy in a total of 79 patients.  Pain outcomes were measured using a visual analog scale (VAS). Bottom line The results of the studies were [read the full story…]

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Absence of evidence for balance interventions to treat peripheral neuropathy

A man doing leg strengthening exercises

A recent systematic review of balance interventions to treat diabetic peripheral neuropathy has reported a very poor evidence base. Only one randomised trial was found by searching the Cochrane Library, CINAHL, EMBASE and Medline.  The reviewers included observational and uncontrolled designs in their review.  A significant amount of heterogeneity was found in terms of the [read the full story…]

Alpha lipoic acid may reduce symptoms of diabetic neuropathy, at a cost.

A foot with ants on it

Sensorimotor neuropathy is one of the most distressing and damaging compllications of diabetes.  Although improved glycaemic control can relieve symptoms, this is often hard to achieve. A recent systematic review set out to address whether treatment with the antioxidant alpha lipoic acid (ALA) can reduce symptoms in people with diabetic sensorimotor neuropathy. The reviewers searched [read the full story…]

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