Limited evidence of better glycaemic control with GLP-1 analogues in type 2 diabetes

A syringe

We recently reported on a review of GLP-1 analogues as a second line of treatment in type 2 diabetes.  A new systematic review reports on a direct comparison with insulin therapy in poorly controlled type 2 diabetes. Clinical question: In type 2 diabetes poorly controlled on oral therapy, do GLP-1 analogues as compared with insulin, [read the full story…]

Metformin may be associated with a reduced risk of liver cancer in type 2 diabetes

Several recent studies have suggested unexpected benefits of metformin.  This prompted a slew of meta-analyses looking for evidence of benefit in preventing cancer.  This evidence needs to be interpreted with caution; this latest review, looking at liver cancer, is a case in point. Clinical question: In type 2 diabetes, does metformin prevent liver cancer? The [read the full story…]

Insulin treatment may be associated with an increased risk of cancer

This systematic review looked at observational studies of a link between treatment with insulin, whether type 1 or type 2 diabetes, and the incidence of cancer of any type. Clinical question: In people with diabetes, is treatment with insulin, as compared to other treatment, associated with an increased risk of cancer? The evidence The reviewers [read the full story…]

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Sedentary behaviour is associated with metabolic syndrome

We already know that sedentary lifestyle is associated with a greater risk of type 2 diabetes.  This systematic review looked for an association with metabolic syndrome, a precursor condition of diabetes. Clinical question: Is a sedentary lifestyle associated with a high risk of developing metabolic syndrome? Metabolic syndrome is the presence of three of the [read the full story…]

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Lack of clear evidence for metformin in type 2 diabetes on insulin therapy

A pill

Metformin is widely used as a first line treatment for type 2 diabetes and it is usually continued when treatment is intensified, such as with other oral agents or by insulin therapy. This systematic review looked at whether metformin is actually beneficial to patients who are using insulin. Clinical question: In people with type 2 [read the full story…]