Metformin appears to be safe in diabetic patients with heart failure

Metformin appears to be safe in diabetic patients with heart failure

Heart failure is more prevalent in diabetes than in the general population.  All too often, patients with such serious co-morbidities are excluded from clinical trials.  As a result, there remains uncertainty around the benefits of diabetes medications in these sub-groups of patients.  Often, we need to look at observational data to get the best available …

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The National Pregnancy in Diabetes Audit aims to improve pregnancy outcomes for women with diabetes

The National Pregnancy in Diabetes Audit aims to improve pregnancy outcomes for women with diabetes

We already know that women with diabetes have a substantially increased risk of adverse pregnancy outcomes.  We also know that improved glycaemic control can reduce these risks.  But are these messages being adequately addressed in current clinical practice? The NHS in England has recently started the National Pregnancy in Diabetes Audit, with the aim of …

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evidence of improved metabolic control in type 2 diabetes after treating periodontal disease

From our Dental Elf: evidence of improved metabolic control in type 2 diabetes after treating periodontal disease

Clinical question: In type 2 diabetes, does non-surgical treatment of periodontal disease lead to improved glycaemic control? Methods: An updated systematic review of randomised trials. Results: The review concluded there was evidence of a small reduction in HbA1c after treatment for gum disease.  However, the studies were of poor quality with some evidence of publication …

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Review finds no evidence for topiramate in treating neuropathic pain

Review finds no evidence for topiramate in treating neuropathic pain

Diabetic neuropathy is a common complication of diabetes.  This condition is very painful and substantially compromises quality of life.  Its progressive nature places a further burden on patients and their carers. Current guidance recommends a range of possible drug treatments, including the antidepressant drugs amitriptyline or duloxetine and the anti-convulsant pregabalin.  A recent Cochrane review …

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vitamin D intake in early life may be associated with a reduced risk of type 1 diabetes

Systematic review finds that vitamin D intake in early life may be associated with a reduced risk of type 1 diabetes

Vitamin D is suspected of having a role in the development of type 1 diabetes.  Previous studies have been small-scale and inconclusive. Now we have a systematic review of the observational evidence about the relationship between consumption of Vitamin D in early life (or during pregnancy) and the risk of developing type 1 diabetes later …

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