Elevated insulin can cause pancreatic cancer
Hello everyone! Dear readers and guests of Alexey Shevchenko’s blog “Healthy lifestyle”, I want to share with you an interesting, in my opinion, news that I found while flipping through the pages of Medicalxpress.
Scientists from the University of British Columbia (Canada) for the first time received evidence that there is a definite link between elevated insulin levels and the development of pancreatic cancer.
sugar and syringe
Pancreatic cancer is one of the most common types of cancer (it ranks sixth in the list of oncological diseases). No more than 10% of cases of pancreatic cancer are associated with genetic features. All other cases are caused by external factors.
Doctors have long and unanimously recognized the link between Smoking and this type of cancer. Smoking is responsible for at least a quarter of all cases of pancreatic cancer.
The disease is clearly related to the peculiarities of the diet, as developed countries account for 70% of cases.
You’ll be very aggressive adenocarcinoma of the pancreas. After this diagnosis, only 25% of patients remain alive after a year, and only five percent manage to live more than five years after the detection of this tumor.
Neuroendocrine cancer gives patients significantly more hope. In this case, about 65% of patients survive five years after diagnosis.
The new study was published in the journal Cell Metabolism. A group of scientists artificially lowered the level of insulin in mice that were predisposed to developing pancreatic cancer, and as a result, the incidence dropped sharply.
One of the co-authors of the study, Professor James Johnson emphasizes that people have pancreatic cancer for quite a long time, either completely asymptomatic, or causing a person minimal inconvenience, which is usually ignored. Therefore, when the patient finally goes to the doctor, the cancer has time to move to the stage when medicine is already powerless.
A new study shows that the Association of pancreatic cancer with obesity and diabetes is closer than previously thought. All these diseases are almost always preceded by hyperinsulinemia, that is, a condition where the body produces too much insulin and cannot properly control blood sugar levels. And, unfortunately, this condition is becoming more and more common. It strongly depends on a person’s diet and lifestyle. Today, both directly provoke the development of hyperinsulinemia.
Senior study co-author Janel Kopp says hyperinsulinemia is linked to more than just malignant pancreatic tumors. It also often precedes the development of breast cancer, which is now the most common form of cancer among women. This experiment was the first to provide direct evidence of this hypothesis in animals.
Apple sugar syringe
The experiment used mice obtained by crossing a breed that is not able to increase insulin levels with a breed that is initially predisposed to pancreatic cancer. These mice received a diet that caused an increase in insulin for a whole year. But since the mice were unable to develop elevated levels, it remained within the normal range. At the end of the experiment, the control group of mice showed a significantly lower incidence of pancreatic cancer.
From this we can conclude: the lower the production of insulin, the less likely the appearance of cancer.
Mouse models are extremely relevant for humans, because for all the striking external differences, the genetic difference between their organisms is extremely small.
The results of the experiment once again convincingly show the deadly danger of every extra piece of sugar or candy. These treats should be present in the diet only in minimal quantities, and the existing practice of feeding children sweets should be eliminated.
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