Complications

diabetic macular oedema

Ranibizumab may be cost-effective for diabetic macular oedema

Blindness is one of the most serious microvascular complications of diabetes.  The most common cause is diabetic macular oedema (DME).  Current treatment with lasers is often unsuccessful. The new injectable drug ranibizumab, which works by selectively inhibiting vascular enothelial growth factor A, has been seen in the RESTORE trial to improve visual acuity and quality …

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Increased risk of acute pancreatitis in people with diabetes

Increased risk of acute pancreatitis in people with diabetes

We already know that pancreatitis can lead to diabetes.  This systematic review of observational studies looked at whether people with diabetes can subsequently develop pancreatitis. Clinical question: In people with diabetes, what is the risk of developing acute pancreatitis? The reviewers were interested in studies that report new (incident) cases of pancreatitis rather than existing …

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Bevacizumab did not improve diabetic macular oedema at 12 weeks

Bevacizumab did not improve diabetic macular oedema at 12 weeks

We recently reported on new guidance from NICE about the treatment of diabetic macular oedema with ranibizumab.  Another systematic review recently looked at another injectable drug with a similar role: bevacizumab, or Avastin. Clinical question: In patients with diabetic macular oedema (DMO), does intravitral injection of bevacizumab (IVB) improve visual acuity? The review focused on …

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Canadian guidelines

Canadian guidelines for managing diabetic retinopathy

The Canadian Journal of Opthalmology has recently published guidelines for managing diabetic retinopathy by the Canadian Ophthalmological Society. Coverage: Methodology Definitions Epidemiology Screening Telehealth and Teleophthalmology Risk Factors For And Prevention Of Progression Of Diabetic Retinopathy Treatment Modalities Pregnancy Neovascularization of The Iris Economic Considerations Support Appraisal hints: Does this guidance conform to AGREE principles? …

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Hyaluric acid derivatives

Hyaluric acid derivatives may promote healing of diabetic foot ulcers

A recent systematic review looked at whether hyaluronic acid derivatives can be effective in dressings to promote wound healing. Clinical question: In people with burns or surgical or chronic wounds, do hyaluronic acid derivatives improve healing? The outcomes of interest were the percentage of patients whose wounds healed completely and the reduction in wound size. …

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