Limited evidence of better glycaemic control with GLP-1 analogues in type 2 diabetes

A syringe

We recently reported on a review of GLP-1 analogues as a second line of treatment in type 2 diabetes.  A new systematic review reports on a direct comparison with insulin therapy in poorly controlled type 2 diabetes. Clinical question: In type 2 diabetes poorly controlled on oral therapy, do GLP-1 analogues as compared with insulin, [read the full story…]

Liraglutide may be safe in type 2 diabetes with mild renal impairment

A doctor and patient discuss medicines

Clinical question In patients with type 2 diabetes and mild renal impairment, is liraglutide safe and effective? Liraglutide is a long-acting glucagon-like peptide-1 (GLP-1) analog sometimes used in type 2 diabetes to help the body produce more insulin.  This review looked at whether it is safe in people who also have renal impairment. The evidence [read the full story…]