Review finds little evidence of benefit for insulin analogs over NPH insulin

Picture of a syringe

A systematic review comparing insulin analogues (glargine and detemir) with NPH insulin was published at the end of 2011. Clinical question: In type 1 diabetes, are insulin analogues better than NPH insulin? It is not clear what outcomes were specified in advance of the study. The evidence: The reviewers found 8 randomised trials comparing glargine [read the full story…]