Evidence for under-reporting of adverse drug events by health care providers

A doctor and patient discuss medicines

Clinical question In type 2 diabetes on oral antidiabetic drug treatment, do patients report more side-effects than health care providers? This systematic review set out to compare patient-reported adverse drug events (such as abdominal pain, dyspepsia or constipation) with provider-reported adverse drug events to see if they are consistent. The evidence The reviewers searched Medline [read the full story…]

FDA warns that pioglitazone may increase the risk of bladder cancer recurrence

Diagram of a male bladder

The US Food and Drug Administration reports that use of the diabetes medication pioglitazone for more than one year may be associated with an increased risk of bladder cancer. Pioglitazone (known as Actos in the UK and US) is a thiazolidinedione or glitazone that is used in type 2 diabetes to reduce insulin resistance. Review [read the full story…]