Possible adverse effects of DPP-4 inhibitors in type 2 diabetes


DPP-4 inhibitors, or “gliptins”, are a new oral therapy for type 2 diabetes.  This review set out to find evidence for their safety in long term use. Clinical question: In type 2 diabetes, do DPP-4 inhibitors have any adverse effects? The evidence: The reviewers found 67 randomised controlled trials that evaluated alogliptin, linagliptin, saxagliptin, sitagliptin, [read the full story…]

Lack of clear evidence for low carb diets in type 2 diabetes

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This systematic review set out to establish whether low-carbohydrate diets, which are known to be effective for short-term weight loss in non-diabetic obese people, work in people with type 2 diabetes. Clinical question: In type 2 diabetes, do low-carbohydrate diets, as compared to alternative dietary advice, lead to improved glycaemic control or increased weight loss? [read the full story…]

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What people with type 2 diabetes think about starting insulin therapy

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Clinical question In type 2 diabetes starting insulin or poorly controlled on oral therapy, what psychological barriers do people experience around initiating insulin therapy? Making the transition to insulin therapy in type 2 diabetes can be very difficult.  This review set out to identify the psychological barriers people experience when faced with the challenge. The [read the full story…]