Systematic review

risk of type 2 diabetes

A diet containing low fat dairy may reduce the risk of type 2 diabetes

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It has been suggested that dairy products might have a preventive effect against type 2 diabetes.  However, the results of observational studies looking at the correlation between the consumption of dairy and incidence of type 2 have been inconclusive. A new systematic review set out to combine the evidence from these different studies into an …

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Review: insulin pumps may improve quality of life and glycaemic control in adults with type 1 diabetes

Review: insulin pumps may improve quality of life and glycaemic control in adults with type 1 diabetes

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What are the benefits of insulin pumps compared with multiple daily injections of insulin?  This report by the US Agency for Healthcare Quality and Research summarises what the evidence says. Clinical question: In diabetics using insulin, does continuous subcutaneous insulin infusion (CSII), compared with multiple daily injections (MDI), improve quality of life or glycaemic control? The …

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No difference between TZDs and DPP-4 inhibitors or sulphonylureas added to metformin in type 2 diabetes

No difference between TZDs and DPP-4 inhibitors or sulphonylureas added to metformin in type 2 diabetes

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Research question: In people with type 2 diabetes inadequately controlled with metformin, which additional oral therapy offers the greatest improvement in HbA1c? The reviewers just looked at glycaemic control in patients whose starting HbA1c was 7% or higher at 12 weeks or longer follow-up. The evidence: Eight randomised trials were found, which looked at various …

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Lack of clear evidence for metformin in type 2 diabetes on insulin therapy

Lack of clear evidence for metformin in type 2 diabetes on insulin therapy

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Metformin is widely used as a first line treatment for type 2 diabetes and it is usually continued when treatment is intensified, such as with other oral agents or by insulin therapy. This systematic review looked at whether metformin is actually beneficial to patients who are using insulin. Clinical question: In people with type 2 …

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Increased risk of acute pancreatitis in people with diabetes

Increased risk of acute pancreatitis in people with diabetes

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We already know that pancreatitis can lead to diabetes.  This systematic review of observational studies looked at whether people with diabetes can subsequently develop pancreatitis. Clinical question: In people with diabetes, what is the risk of developing acute pancreatitis? The reviewers were interested in studies that report new (incident) cases of pancreatitis rather than existing …

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