Guidance for intensification of insulin therapy in type 2 diabetes.

Adjusting the dose

The Indian Journal of Endocrinology has recently publised a consensus statement on the intensification of insulin therapy in type 2 diabetes.

The guidelines cover making the switch from a premix analog biphasic insulin aspart (BIAsp) 30 to a mid-/high-ratio premix regimen in patients who are failing to achieve good glycaemic control.

The guidelines were produced by a panel of independent experts with extensive clinical experience in premix analog therapy.  They developed a guideline algorithm and simple tool to aid dose adjustment.

Appraisal guide

Users of these guidelines should consider:

  • The quality of the evidence appraisal incorporated into the guideline development process.
  • The usefulness of this guideline alongside other existing guidance in this area.
  • The patient population this guideline applies to.


Brito M, Ligthelm RJ et al. Intensifying existing premix therapy (BIAsp 30) with BIAsp 50 and BIAsp 70: A consensus statement. Indian J Endocrinol Metab 2011; 15 (3): 152-160.


Share this post: Share on Facebook Tweet this on Twitter Share on LinkedIn Share on Google+ Share via email


I am an information scientist with an interest in making knowledge from systematic research more accessible to people who need it. This means you. I've been attempting this in the area of Evidence-Based Health Care since 1995. So far the results have been mixed. For some reason we expected busy clinicians to search databases and appraise papers instead of seeing patients. We also expected publishers to make the research freely available to the people who paid for it.. Ha! Hence The National Elf service.

More posts - Website

Follow me here –