This is a consensus statement from an expert review by the Canadian Hypertension Education Program and the Canadian Diabetes Association. The reviewers conducted a systematic search for randomised trials and systematic reviews about diabetes and hypertension.
They conclude that “reducing blood pressure pharmacologically is single-handedly the most effective way to reduce rates of death and disability in patients with diabetes, particularly associated cardiovascular risks.” This can mean that combination treatments are needed to achieve good control of blood pressure
Furthermore, they note that the costs of additional treatment are outweighed by the consequences of not treating hypertension.
Readers of this paper should consider:
- The quality of evidence in respect of the benefits associated with individual treatments, combination treatments and cost-effectiveness analysis.
- Applicability to individual patients.
- Adverse effects of the possible treatments and combinations of treatments.
Hutchins V, Zhang B, Fleurence RL, Krishnarajah G, Graham J. A systematic review of adherence, treatment satisfaction and costs, in fixed-dose combination regimens in type 2 diabetes. Can Fam Physician. 2011 Sep;57(9):997-1002.
The full text is available at the above link.