High levels of patient satisfaction with incretin-based therapies in type 2 diabetes.

A syringe

A new systematic review looked at patient-reported outcomes associated with GLP-1 receptor agonists for managing type 2 diabetes.

Clinical question:

In type 2 diabetes not on insulin, do incretin-based therapies compared to usual care improve patient satisfaction or quality of life?

The main outcome measures were the Diabetes Treatment Satisfaction Questionnaire (DTSQ) and/or Impact of Weight on Quality Of Life-Lite (IWQOL-Lite).

The evidence:

The reviewers found eight clinical trials of the GLP-1 receptor agonists liraglutide, exenatide and long-acting exenatide which reported these outcome measures.

They concluded:

Treatment satisfaction (including perceptions of convenience and flexibility) was high, and generally higher with GLP-1 agonists in association with their greater glucose-lowering efficacy and tendency to facilitate weight loss.

Appraisal hints

Users of this research should consider:

  • Whether the reviewers found all of the relevant publications.
  • Did the reviewers produce a clear, prospective protocol for the review?
  • Whether the inclusion criteria and quality assessment of individual studies was carried out by blind, independent reviewers.
  • Whether it makes sense to combine the individual trials into an overall summary.
  • What analytical approach was taken to identifying common themes between treatment modalities.
  • Whether these benefits would be seen in clinical practice.


Davies M, Speight J. Patient-reported outcomes in trials of incretin-based therapies in patients with type 2 diabetes. Diabetes Obes Metab. 2012 Mar 15.

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I am an information scientist with an interest in making knowledge from systematic research more accessible to people who need it. This means you. I've been attempting this in the area of Evidence-Based Health Care since 1995. So far the results have been mixed. For some reason we expected busy clinicians to search databases and appraise papers instead of seeing patients. We also expected publishers to make the research freely available to the people who paid for it.. Ha! Hence The National Elf service.

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